Lysozyme Enhancement of Tumor Cell Immunoprotection in a Murine Fibrosarcoma1
نویسندگان
چکیده
We examined the ability of human lysozyme (HLZM) to enhance the immunogenicity of a methylcholanthrene-induced murine fibrosarcoma in C57BL/10 mice. Following s.c. injec tion of 10" live tumor cells, 100% of mice developed palpable tumors within 16 ±3 (S.D.) days. Prechallenge immunization with 106 irradiated tumor cells with or without complete Freund's adjuvant resulted in protection from tumor develop ment in 14 and 22% of mice, respectively. Incubation of tumor cells with HLZM prior to immunization approximately doubled the degree of protection, with 42 to 44% of mice remaining free of tumor. This enhanced protection was dependent on the enzymatic activity of HLZM. These data suggest that HLZM enhances tumor cell immunogenicity in this model.
منابع مشابه
Lysozyme enhancement of tumor cell immunoprotection in a murine fibrosarcoma.
We examined the ability of human lysozyme (HLZM) to enhance the immunogenicity of a methylcholanthrene-induced murine fibrosarcoma of C57BL/10 mice. Following s.c. injection of 10(4) live tumor cells, 100% of mice developed palpable tumors within 16 +/- 3 (S.D.) days. Prechallenge immunization with 10(6) irradiated tumor cells with or without complete Freund's adjuvant resulted in protection fr...
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